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The positive effects of dairy peptides on high blood pressure:

Independent clinical studies have shown 0.75 mg of lactotripeptides (dairy peptides) is sufficient for positive and beneficial effects in blood pressure control for both prehypertensives and mild hypertensives.

Lactotripeptides & blood pressure control

4 European and 14 Japanese human studies 3 different milk derived ingredients tested, all containing lactotripeptides. 0.75 mg of lactotripeptides (latest patented formulation) is sufficient to show positive and beneficial effects in both prehypertensives and mild hypertensives.

 

No blood pressure lowering observed in normal healthy persons

Clinical trial results

Angiotensin Converting Enzyme Inhibitor Peptides from Lactro-peptide-Enriched milk beverage are absorbed intact into the circulationHuman volunteers ingested a yogurt drink enriched with lactotripeptides. Subsequently, plasma samples were collected and analysed.

  • The presence of IPP was demonstrated in measurable amounts in the circulation.
  • IPP survives gastro-intestinal tract

 

The diagram shows: Foltz et al (2007), Journal of Nutrition 137, 953-958 Angiotensin Converting Enzyme Inhibitor Peptides from Lactro-peptide-Enriched milk beverage are absorbed intact into the circulation

Results table: click to expand

Author / reference
Hypertension 'level’
Subject
Lactotripeptide (mg/day)
Duration
Effect (SPB)
1.Hata (1996)
Mild/moderate
30
2.6
8
9.7
2.Kajimoto (2001)
Mild/moderate
30
4.1
8
-14
3.Kajimoto (2001)
Mild
81
4.2
8
-11
4.Itakura (2001)
Mild/moderate1)
15
2.6
8
7.6
Normal
22
2.6
8
n.s.
5.Kajimoto (2001)
Normal
43
12.3
2
n.s.
6.Yasuda (2001)
Normal
20
29.2
1
n.s
7.Hirata (2002)
Mild/moderate
32
4.3
8
12.1
8.Kajimoto (2002)
Mild
64
1.9
8
13.0
9.Seppo (2002)
Mild
17
5.5
8
-9
10.Seppo (2003)
Mild/moderate
39
5.2
21
6.7
11.Mizushima (2004)
Mild1)
42
3.1
4
1.5
12.Nakamura (2004)
Prehypertensive
106
1.9
12
4.1
13.Sano (2004)
Prehypertensive
43
9.2
4
6.4
14.Tuomilehto (2004)
Mild
59
5.1
10
-12
15.Aihara (2005)
Mild
40
13
4
11.2
Prehypertensive
40
13
4
3.2
16.Jauhiainen (2005)
Prehypertensive/mild
94
52.5
10
4.1
17.Mizuno (2005)
Mild
24
3.6
6
12.2
Prehypertensive
24
3.6
6
2.0
18.Sano (2006)
Prehypertensive
144
3.1
12
4.4
Mild
40
3.1
12
-6
Prehypertensive
104
3.1
12
-3

 

A high, guaranteed level of lactotripeptides

milk protein - dairy peptide bioactive enzymesMilk proteins are known to contain several biologically active peptides. However, they are inactive within the original protein. To become effective, these bioactive peptides first need to be released through enzymatic pre-digestion.

 

 

 

 

 

 

 

 

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