Praventin is a natural food supplement that has been shown
in clinical trials to help reduce the number and severity of skin blemishes.
More details on Praventin: click to expand
Praventin is produced by a proprietary process that derives
a bioactive complex from whey rich in the lactoferrin fraction. Praventin
is based on milk's many bioactive components with specific physiological
effects to support a healthy complexion from the inside. The effect of
Praventin on the skin is associated with the anti-microbial, antioxidant
and anti-inflammatory properties of the Praventin ingredient. The dietary
supplement effect of Praventin for a healthy complexion from the inside
has been demonstrated in test market studies with teenage consumers.
Praventin works in two ways. Firstly, it inhibits the
growth of the propionibacterium, which is present on most people's skin
and responsible for blemishes, thereby lessening the number of new skin
irritants forming. Secondly its anti-inflammatory properties mean that
the size of blemishes is reduced and blemishes heal quicker resulting
in a smoother complexion.
The effects of Praventin have been proven in medical trials, showing a median
decrease in blemishes by 71% within one month and 95% within two months.
In the studies, subjects took 200mg of Praventin each day to achieve a noticeable
difference in the texture of their skin.
More details on the the
clinical trials: click to expand
acnes (ATCC 11827) were cultivated in reinforced clostridial medium at
37ºC in an anaerobic chamber under an atmosphere of 90% N2, 5% CO2
and 5% H2. Bacteria were suspended at a concentration range of 10e6 CFU/
ml in reinforced clostridial medium. 16% Praventin solutions were made
in sterile water. In 96 wells microplates, 100ul bacterial suspension
was added to 50µl Praventin solution and 50ul 2* concentrated reinforced
clostridial medium. OD (600 nm) was measured at 24, 36, 48, 60 and 72
In figure 4 it is shown that Praventin inhibits the growth
of Propionibacterium acnes. It is possible that lactoferrin may contribute
to the anti-microbial properties of Praventin against propionibacteria
or other acne-related bacteria. This may be accomplished by mechanisms
such as iron scavenging, disruption of cell membrane or inhibition of
No. In studies
with teenage consumers, no adverse side effects were reported. It was also
seen to contribute positively to the physical and emotional well-being of
Praventin inhibits the development of the bacteria that
cause blemishes and reducing the inflammation associated with existing blemishes.
More details on the effects of Praventin: click to expand
The mechanism of action of Praventin for the internal
support of healthy skin is not clear; it is known that part of the bioactive
protein complex contains lactoferrin. It is believed that other compounds
naturally present in the whey protein complex work in synergy with the
lactoferrin fraction, playing an important role in supporting the healthy
Lactoferrin is present naturally in exocrine secretions
that are commonly exposed to normal flora: milk, tears, nasal exudate,
bronchial mucus, gastrointestinal fluids, and saliva. Lactoferrin is expressed
in polymorphonuclear leukocytes and is secreted by various circulating
immune cells at infected sites. A primary function of lactoferrin is scavenging
free iron in body fluids and inflamed sites to suppress free radical-mediated
damage (much like an antioxidant) and diminish availability of the element
to invading microbes.
Yes, Praventin helps repair damaged cells caused by blemishes.
No, there is currently no cure for acne. However Praventin will help in the treatment of acne by reducing the bacteria associated with skin blemishes through its antimicrobial, antioxidant and anti-inflammatory properties.
Yes. The reduced redness in the consumer
studies is indicative for an anti-inflammatory effect. Praventin, is rich
in Lactoferrin and possesses anti-microbial, anti-inflammatory and antioxidant
properties which are relevant to the support of a healthy complexion.
More details on the anti-inflammatory properties
of Praventin: click to expand
The lactoferrin fraction in Praventin may exert anti-inflammatory
effects in the skin by skewing immune response in the anti-inflammatory
direction. This is initiated through binding of free iron, which catalyzes
formation of free radicals. Praventin may neutralize the release of the
inflammation mediator lipopolysaccharides (LPS) by acne-related bacteria,
or modulate the activity of immune cells.
Studies have shown that Praventin is more effective taken
as a food supplement. The statistical data obtained demonstrates that orally
administered Praventin is a beneficial ingredient to support the reduction
of blemishes and redness associated with a poor complexion. The outcome
of these studies form a solid base to position Praventin as a natural ingredient
in a dietary supplement format to help support relief to blemished skin.
More details on oral vs. topical Praventin:
click to expand
Praventin may exert activity by suppressing the oxidation
of squalene (a compound of skin lipids). In previous studies, the lipids
found on the skin surface, and from open and closed comedones in acne
patients were analysed. It was demonstrated that these lipids were enriched
in polar lipids, as compared with skin surface lipids acquired from acne-free
controls. In both open and closed comedones, these polar lipids appeared
to be derived mainly from the oxidation of squalene. It was suggested
that squalene oxidation is the link between comedogenesis and bacterial
colonization, and plays an essential role in the pathogenesis of acne.
In a study with 10 healthy volunteers, it was demonstrated that topical
application of Praventin was able to prevent cutaneous lipid peroxidation,
as measured by the squalene: squalenehydroperoxide ratio (unpublished
results). These results indicate that Praventin may support a healthy
complexion by preventing squalene oxidation, and subsequent comedogenesis.
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