What is Praventin?

What is Praventin (lactoferrin)?

Praventin is a natural food supplement clinically proven to help achieve a smoother more radiant complexion by reducing the bacteria associated with skin blemishes (spots & acne), helping to soothe and heal skin.

Praventin is the active ingredient in help: clear skin and has antimicrobial, antioxidant and anti-inflammatory properties, which are key in the fight against acne (acne vulgaris).

What does Praventin do?

Praventin is a natural food supplement that has been shown in clinical trials to help reduce the number and severity of skin blemishes.

More details on Praventin: click to expand

Praventin is produced by a proprietary process that derives a bioactive complex from whey rich in the lactoferrin fraction. Praventin is based on milk's many bioactive components with specific physiological effects to support a healthy complexion from the inside. The effect of Praventin on the skin is associated with the anti-microbial, antioxidant and anti-inflammatory properties of the Praventin ingredient. The dietary supplement effect of Praventin for a healthy complexion from the inside has been demonstrated in test market studies with teenage consumers.

Praventin works in two ways. Firstly, it inhibits the growth of the propionibacterium, which is present on most people's skin and responsible for blemishes, thereby lessening the number of new skin irritants forming. Secondly its anti-inflammatory properties mean that the size of blemishes is reduced and blemishes heal quicker resulting in a smoother complexion.

Praventin: does it work?

Praventin Clinical trial image - subject week 0 and week8Yes. The effects of Praventin have been proven in medical trials, showing a median decrease in blemishes by 71% within one month and 95% within two months. In the studies, subjects took 200mg of Praventin each day to achieve a noticeable difference in the texture of their skin.

More details on the the clinical trials: click to expand

Praventin inhibits the growth of Propionibacterium acnes in in-vitroPropionibacterium acnes (ATCC 11827) were cultivated in reinforced clostridial medium at 37ºC in an anaerobic chamber under an atmosphere of 90% N2, 5% CO2 and 5% H2. Bacteria were suspended at a concentration range of 10e6 CFU/ ml in reinforced clostridial medium. 16% Praventin solutions were made in sterile water. In 96 wells microplates, 100ul bacterial suspension was added to 50µl Praventin solution and 50ul 2* concentrated reinforced clostridial medium. OD (600 nm) was measured at 24, 36, 48, 60 and 72 hours.

In figure 4 it is shown that Praventin inhibits the growth of Propionibacterium acnes. It is possible that lactoferrin may contribute to the anti-microbial properties of Praventin against propionibacteria or other acne-related bacteria. This may be accomplished by mechanisms such as iron scavenging, disruption of cell membrane or inhibition of biofilm formation.

Are there any side effects?

No. In studies with teenage consumers, no adverse side effects were reported. It was also seen to contribute positively to the physical and emotional well-being of young adults.

How does Praventin work?

Praventin inhibits the development of the bacteria that cause blemishes and reducing the inflammation associated with existing blemishes.

More details on the effects of Praventin: click to expand

The mechanism of action of Praventin for the internal support of healthy skin is not clear; it is known that part of the bioactive protein complex contains lactoferrin. It is believed that other compounds naturally present in the whey protein complex work in synergy with the lactoferrin fraction, playing an important role in supporting the healthy skin effects.

Lactoferrin is present naturally in exocrine secretions that are commonly exposed to normal flora: milk, tears, nasal exudate, bronchial mucus, gastrointestinal fluids, and saliva. Lactoferrin is expressed in polymorphonuclear leukocytes and is secreted by various circulating immune cells at infected sites. A primary function of lactoferrin is scavenging free iron in body fluids and inflamed sites to suppress free radical-mediated damage (much like an antioxidant) and diminish availability of the element to invading microbes.

Can Praventin help with acne scarring?

Yes, Praventin helps repair damaged cells caused by blemishes.

Is Praventin an acne cure?

No, there is currently no cure for acne. However Praventin will help in the treatment of acne by reducing the bacteria associated with skin blemishes through its antimicrobial, antioxidant and anti-inflammatory properties.

Does Praventin have anti-inflammatory properties?

Yes. The reduced redness in the consumer studies is indicative for an anti-inflammatory effect. Praventin, is rich in Lactoferrin and possesses anti-microbial, anti-inflammatory and antioxidant properties which are relevant to the support of a healthy complexion.

More details on the anti-inflammatory properties of Praventin: click to expand

The lactoferrin fraction in Praventin may exert anti-inflammatory effects in the skin by skewing immune response in the anti-inflammatory direction. This is initiated through binding of free iron, which catalyzes formation of free radicals. Praventin may neutralize the release of the inflammation mediator lipopolysaccharides (LPS) by acne-related bacteria, or modulate the activity of immune cells.

Why is Praventin taken as a food supplement rather than using as a spot cream?

Studies have shown that Praventin is more effective taken as a food supplement. The statistical data obtained demonstrates that orally administered Praventin is a beneficial ingredient to support the reduction of blemishes and redness associated with a poor complexion. The outcome of these studies form a solid base to position Praventin as a natural ingredient in a dietary supplement format to help support relief to blemished skin.

More details on oral vs. topical Praventin: click to expand

Praventin may exert activity by suppressing the oxidation of squalene (a compound of skin lipids). In previous studies, the lipids found on the skin surface, and from open and closed comedones in acne patients were analysed. It was demonstrated that these lipids were enriched in polar lipids, as compared with skin surface lipids acquired from acne-free controls. In both open and closed comedones, these polar lipids appeared to be derived mainly from the oxidation of squalene. It was suggested that squalene oxidation is the link between comedogenesis and bacterial colonization, and plays an essential role in the pathogenesis of acne. In a study with 10 healthy volunteers, it was demonstrated that topical application of Praventin was able to prevent cutaneous lipid peroxidation, as measured by the squalene: squalenehydroperoxide ratio (unpublished results). These results indicate that Praventin may support a healthy complexion by preventing squalene oxidation, and subsequent comedogenesis.


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