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Clinical Studies

 

Lactotripeptides & blood pressure control
 
 
   

Lactotripeptides & blood pressure control

 

4 European and 14 Japanese human studies 3 different milk derived ingredients tested, all containing lactotripeptides

 

0.75 mg of lactotripeptides (latest patented formulation) is sufficient to show clinically relevant effects in both prehypertensives and mild hypertensives.

No blood pressure lowering observed in normal healthy persons

1 sachet of help: blood pressure contains 0.38g of Dairy Peptide, half of the required daily dose to help maintain healthy blood pressure. Each portion also contains 3.62g of Oligofructose a source of soluble fibre.

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Author / reference
Hypertension 'level’
Subject
Lactotripeptide
(mg/day)
Duration
(weeks)
Effect
(SPB)
1.Hata (1996)
Mild/moderate
30
2.6
8
9.7
2.Kajimoto (2001)
Mild/moderate
30
4.1
8
-14
3.Kajimoto (2001)
Mild
81
4.2
8
-11
4.Itakura (2001)
Mild/moderate1)
15
2.6
8
7.6
Normal
22
2.6
8
n.s.
5.Kajimoto (2001)
Normal
43
12.3
2
n.s.
6.Yasuda (2001)
Normal
20
29.2
1
n.s
7.Hirata (2002)
Mild/moderate
32
4.3
8
12.1
8.Kajimoto (2002)
Mild
64
1.9
8
13.0
9.Seppo (2002)
Mild
17
5.5
8
-9
10.Seppo (2003)
Mild/moderate
39
5.2
21
6.7
11.Mizushima (2004)
Mild1)
42
3.1
4
1.5
12.Nakamura (2004)
Prehypertensive
106
1.9
12
4.1
13.Sano (2004)
Prehypertensive
43
9.2
4
6.4
14.Tuomilehto (2004)
Mild
59
5.1
10
-12
15.Aihara (2005)
Mild
40
13
4
11.2
Prehypertensive
40
13
4
3.2
16.Jauhiainen (2005)
Prehypertensive/mild
94
52.5
10
4.1
17.Mizuno (2005)
Mild
24
3.6
6
12.2
Prehypertensive
24
3.6
6
2.0
18.Sano (2006)
Prehypertensive
144
3.1
12
4.4
Mild
40
3.1
12
-6
Prehypertensive
104
3.1
12
-3
 

Human volunteers ingested a yogurt drink enriched with lactotripeptides.

Subsequently, plasma samples were collected and analysed.

The presence of IPP was demonstrated in measurable amounts in the circulation.

IPP survives gastro-intestinal tract

Angiotensin Converting Enzyme Inhibitor

 

A high, guaranteed level of Lactotripeptides

Milk proteins are known to contain several biologically active peptides. However, they are inactive within the original protein. To become effective, these bioactive peptides first need to be released through enzymatic pre-digestion

   Milk Protein - Lactotripeptides

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