help:clear skin

About Praventin

Praventin is produced by a proprietary process that derives a bioactive complex from whey rich in the lactoferrin fraction. Praventin is based on milk's many bioactive components with specific physiological effects to support a healthy complexion from the inside. The effect of Praventin on the skin is associated with the anti-microbial, anti-oxidant and anti-inflammatory properties of the Praventin ingredient. The dietary supplement effect of Praventin for a healthy complexion from the inside has been demonstrated in test market studies with teenage consumers.

Praventin can be used to support the reduction of the number and severity of blemishes associated with a poor complexion and can contribute positively to the physical and emotional well-being of young adults. In contrast to reported side effects for retinoid, antibiotic or hormonal based anti-acne therapies, studies with teenage consumers indicate that Praventin intake is safe with no adverse side effects reported.

Improving skin appearance through the bioactive effects of natural lactoferrin from milk protein

The mechanism of action of Praventin for the internal support of healthy skin is not clear; it is known that part of the bioactive protein complex contains lactoferrin. It is believed that other compounds naturally present in the whey protein complex work in synergy with the lactoferrin fraction, playing an important role in supporting the healthy skin effects.

Lactoferrin is present naturally in exocrine secretions that are commonly exposed to normal flora: milk, tears, nasal exudate, bronchial mucus, gastrointestinal fluids, and saliva. Lactoferrin is expressed in polymorphonuclear leukocytes and is secreted by various circulating immune cells at infected sites. A primary function of lactoferrin is scavenging free iron in body fluids and inflamed sites to suppress free radical-mediated damage and diminish availability of the element to invading microbes. Additionally, bovine lactoferrin possesses anti-microbial, anti-inflammatory and anti-oxidant properties which are relevant to the support of a healthy complexion.

help: clear skin and Praventin

help: clear skin food supplement contains Praventin which is clinically proven to clear acne. Praventin, a bioactive protein rich in lactoferrin, works by inhibiting the development of the bacteria that cause acne and reducing the inflammation associated with existing acne blemishes.

The effects of Praventin were proven in medical trials with teenage consumers, showing a median decrease in acne blemishes by 71% within one month and 95% within two months. In the studies, subjects took 200mg of Praventin each day to achieve a noticeable difference in the texture of their skin. Each 4g sachet of help: clear skin food supplement contains 100mg of Praventin to nourish skin from the inside out.

As well as Praventin, help: clear skin also contains 0.25g of 200:1 high extract Aloe Vera, which has an antimicrobial and nourishing effect on the skin, and 3.65g of Oligofructose which is a natural source of fibre.

Praventin may limit the growth of acne bacteria

Propionibacterium acnes (ATCC 11827) was cultivated in reinforced clostridial medium at 37ºC in an anaerobic chamber under an atmosphere of 90% N2, 5% CO2 and 5% H2. Bacteria were suspended at a concentration range of 10e6 CFU/ ml in reinforced clostridial medium. 16% Praventin solutions were made in sterile water. In 96 wells microplates, 100ul bacterial suspension was added to 50µl Praventin solution and 50ul 2* concentrated reinforced clostridial medium. OD (600 nm) was measured at 24, 36, 48, 60 and 72 hours.

In figure 4 it is shown that Praventin inhibits the growth of Propionibacterium acnes. It is possible that lactoferrin may contribute to the anti-microbial properties of Praventin against propionibacteria or other acne-related bacteria. This may be accomplished by mechanisms such as ironscavenging, disruption of cell membrane or inhibition of biofilm formation.

Praventin may help calm the effects of inflamed skin areas

The lactoferrin fraction in Praventin may exert anti-inflammatory effects in the skin by skewing immune response in the anti-inflammatory direction. This is initiated through binding of free iron, which catalyzes formation of free radicals. Praventin may neutralize the release of the inflammation mediator lipopolysaccharides (LPS) by acne-related bacteria, or modulate the activity of immune cells. The reduced redness in the consumer studies is indicative for an anti-inflammatory effect of Praventin.

Praventin assists in the inhibition of squalene oxidation

Praventin may exert activity by suppressing the oxidation of squalene (a compound of skin lipids). In previous studies, the lipids found on the skin surface, and from open and closed comedones in acne patients were analysed. It was demonstrated that these lipids were enriched in polar lipids, as compared with skin surface lipids acquired from acne-free controls. In both open and closed comedones, these polar lipids appeared to be derived mainly from the oxidation of squalene. It was suggested that squalene oxidation is the link between comedogenesis and bacterial colonization, and plays an essential role in the pathogenesis of acne. In a study with 10 healthy volunteers, it was demonstrated that topical application of Praventin was able to prevent cutaneous lipid peroxidation, as measured by the squalene: squalenehydroperoxide ratio (unpublished results). These results indicate that Praventin may support a healthy complexion by preventing squalene oxidation, and subsequent comedogenesis.

The benefits of Praventin for the support of a healthier complexion

The statistical data obtained from studies demonstrate that orally administered Praventin is a beneficial ingredient to support the reduction of blemishes and redness associated with a poor complexion.

The outcome of these studies form a solid base to position Praventin as a natural ingredient in a dietary supplement format to help support relief to blemished skin. In contrast to current systemic and topical anti-acne therapies (based on antibiotics, retinoids or other compounds), Praventin supplementation is not accompanied by side effects and can be used on a continual basis.